Viral load in patients infected with pandemic H1N1 2009 influenza A virus
Identifieur interne : 002681 ( Main/Exploration ); précédent : 002680; suivant : 002682Viral load in patients infected with pandemic H1N1 2009 influenza A virus
Auteurs : Kelvin K. W. To [République populaire de Chine] ; Kwok-Hung Chan [République populaire de Chine] ; Iris W. S. Li [République populaire de Chine] ; Tak-Yin Tsang [République populaire de Chine] ; Herman Tse [République populaire de Chine] ; Jasper F. W. Chan [République populaire de Chine] ; Ivan F. N. Hung [République populaire de Chine] ; Sik-To Lai [République populaire de Chine] ; Chi-Wai Leung [République populaire de Chine] ; Yat-Wah Kwan [République populaire de Chine] ; Yu-Lung Lau [République populaire de Chine] ; Tak-Keung Ng [République populaire de Chine] ; Vincent C. C. Cheng [République populaire de Chine] ; Joseph S. M. Peiris [République populaire de Chine] ; Kwok-Yung Yuen [République populaire de Chine, Hong Kong]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2010-01.
English descriptors
- Teeft :
- Administrative region, Adolescent medicine, Antiviral therapy, Aspirate, Chain reaction, Chan, Cheng, Clin, Clinical aspects, Clinical characteristics, Diarrhoea blood test, Different body sites, Disease control, Exact test, Fever cough sputum production, Further studies, Gastrointestinal symptoms, Historical controls, Hong kong, Human infection, Immunosuppressive states, Infection, Infection control measures, Infectious diseases, Master sybr, Median duration, Nasopharyngeal, Nasopharyngeal aspirate, Nasopharyngeal aspirates, Nasopharyngeal swabs, Oseltamivir, Oseltamivir therapy, Pandemic, Peiris, Polymerase chain reaction, Previous studies, Princess margaret hospital, Pulmonary diseases, Queen mary hospital, Respiratory specimen, Respiratory specimens, Respiratory syncytial virus, Respiratory tract, Respiratory viruses, Sars coronavirus, Seasonal virus, Seasonal virus infection, Second world health organization consultation, Small sample size, Standard deviation, Symptom, Symptoms days, Throat swabs, Urine, Viral, Viral culture, Viral load, Viral loads, Virol, Virus, Virus infection, Virus investigation team, White blood cell, World health organization, Young children, Yuen.
Abstract
Viral shedding profile of infections caused by the pandemic H1N1 2009 influenza A virus has not been reported. The aim of this study was to determine the viral load in different body sites. Viral loads of pandemic H1N1 virus in respiratory specimens, stool, urine, and serum were determined by quantitative reverse transcriptase‐polymerase chain reaction (RT‐PCR). Respiratory specimens from patients with seasonal influenza were used as historical controls. Initial pre‐treatment viral load were compared between these two groups. Serial respiratory specimens from patients with pandemic H1N1 virus infection were obtained for analysis of viral dynamics. Twenty‐two pandemic H1N1 cases and 44 seasonal influenza historical controls were included. The mean initial viral load before oseltamivir therapy was 1.84 × 108 copies/ml for pandemic H1N1 virus compared with 3.28 × 108 copies/ml in seasonal influenza historical controls (P = 0.085). Among patients with pandemic H1N1 virus infection, peak viral load occurred on the day of onset of symptoms, and declined gradually afterwards, with no virus being detectable in respiratory specimens by RT‐PCR 8 days and by culture 5 days after the onset of symptoms respectively, except in one patient. Pandemic H1N1 virus was detected in stool and in urine from 4/9 and 1/14 patients, respectively. Viral culture was also positive from the stool sample with the highest viral load. Younger age was associated with prolonged shedding in the respiratory tract and higher viral load in the stool. Data from this quantitative analysis of viral shedding may have implications for formulating infection control measures. J. Med. Virol. 82:1–7, 2010. © 2009 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.21664
Affiliations:
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W." last="To">Kelvin K. W. To</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Kwok Ung" sort="Chan, Kwok Ung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Li, Iris W S" sort="Li, Iris W S" uniqKey="Li I" first="Iris W. S." last="Li">Iris W. S. Li</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Tsang, Tak In" sort="Tsang, Tak In" uniqKey="Tsang T" first="Tak-Yin" last="Tsang">Tak-Yin Tsang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F. W." last="Chan">Jasper F. W. Chan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Hung, Ivan F N" sort="Hung, Ivan F N" uniqKey="Hung I" first="Ivan F. N." last="Hung">Ivan F. N. Hung</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Lai, Sik O" sort="Lai, Sik O" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Leung, Chi Ai" sort="Leung, Chi Ai" uniqKey="Leung C" first="Chi-Wai" last="Leung">Chi-Wai Leung</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Kwan, Yat Ah" sort="Kwan, Yat Ah" uniqKey="Kwan Y" first="Yat-Wah" last="Kwan">Yat-Wah Kwan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Lau, Yu Ung" sort="Lau, Yu Ung" uniqKey="Lau Y" first="Yu-Lung" last="Lau">Yu-Lung Lau</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Tak Eung" sort="Ng, Tak Eung" uniqKey="Ng T" first="Tak-Keung" last="Ng">Tak-Keung Ng</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Clinical Pathology, Princess Margaret Hospital, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S. M." last="Peiris">Joseph S. M. Peiris</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, Kwok Ung" sort="Yuen, Kwok Ung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Hong Kong</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Correspondence address: Carol Yu's Centre for Infection and Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">82</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="7">7</biblScope><biblScope unit="page-count">7</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01">2010-01</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Administrative region</term><term>Adolescent medicine</term><term>Antiviral therapy</term><term>Aspirate</term><term>Chain reaction</term><term>Chan</term><term>Cheng</term><term>Clin</term><term>Clinical aspects</term><term>Clinical characteristics</term><term>Diarrhoea blood test</term><term>Different body sites</term><term>Disease control</term><term>Exact test</term><term>Fever cough sputum production</term><term>Further studies</term><term>Gastrointestinal symptoms</term><term>Historical controls</term><term>Hong kong</term><term>Human infection</term><term>Immunosuppressive states</term><term>Infection</term><term>Infection control measures</term><term>Infectious diseases</term><term>Master sybr</term><term>Median duration</term><term>Nasopharyngeal</term><term>Nasopharyngeal aspirate</term><term>Nasopharyngeal aspirates</term><term>Nasopharyngeal swabs</term><term>Oseltamivir</term><term>Oseltamivir therapy</term><term>Pandemic</term><term>Peiris</term><term>Polymerase chain reaction</term><term>Previous studies</term><term>Princess margaret hospital</term><term>Pulmonary diseases</term><term>Queen mary hospital</term><term>Respiratory specimen</term><term>Respiratory specimens</term><term>Respiratory syncytial virus</term><term>Respiratory tract</term><term>Respiratory viruses</term><term>Sars coronavirus</term><term>Seasonal virus</term><term>Seasonal virus infection</term><term>Second world health organization consultation</term><term>Small sample size</term><term>Standard deviation</term><term>Symptom</term><term>Symptoms days</term><term>Throat swabs</term><term>Urine</term><term>Viral</term><term>Viral culture</term><term>Viral load</term><term>Viral loads</term><term>Virol</term><term>Virus</term><term>Virus infection</term><term>Virus investigation team</term><term>White blood cell</term><term>World health organization</term><term>Young children</term><term>Yuen</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viral shedding profile of infections caused by the pandemic H1N1 2009 influenza A virus has not been reported. The aim of this study was to determine the viral load in different body sites. Viral loads of pandemic H1N1 virus in respiratory specimens, stool, urine, and serum were determined by quantitative reverse transcriptase‐polymerase chain reaction (RT‐PCR). Respiratory specimens from patients with seasonal influenza were used as historical controls. Initial pre‐treatment viral load were compared between these two groups. Serial respiratory specimens from patients with pandemic H1N1 virus infection were obtained for analysis of viral dynamics. Twenty‐two pandemic H1N1 cases and 44 seasonal influenza historical controls were included. The mean initial viral load before oseltamivir therapy was 1.84 × 108 copies/ml for pandemic H1N1 virus compared with 3.28 × 108 copies/ml in seasonal influenza historical controls (P = 0.085). Among patients with pandemic H1N1 virus infection, peak viral load occurred on the day of onset of symptoms, and declined gradually afterwards, with no virus being detectable in respiratory specimens by RT‐PCR 8 days and by culture 5 days after the onset of symptoms respectively, except in one patient. Pandemic H1N1 virus was detected in stool and in urine from 4/9 and 1/14 patients, respectively. Viral culture was also positive from the stool sample with the highest viral load. Younger age was associated with prolonged shedding in the respiratory tract and higher viral load in the stool. Data from this quantitative analysis of viral shedding may have implications for formulating infection control measures. J. Med. Virol. 82:1–7, 2010. © 2009 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="To, Kelvin K W" sort="To, Kelvin K W" uniqKey="To K" first="Kelvin K. W." last="To">Kelvin K. W. To</name></noRegion><name sortKey="Chan, Jasper F W" sort="Chan, Jasper F W" uniqKey="Chan J" first="Jasper F. W." last="Chan">Jasper F. W. Chan</name><name sortKey="Chan, Kwok Ung" sort="Chan, Kwok Ung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C. C." last="Cheng">Vincent C. C. Cheng</name><name sortKey="Hung, Ivan F N" sort="Hung, Ivan F N" uniqKey="Hung I" first="Ivan F. N." last="Hung">Ivan F. N. Hung</name><name sortKey="Kwan, Yat Ah" sort="Kwan, Yat Ah" uniqKey="Kwan Y" first="Yat-Wah" last="Kwan">Yat-Wah Kwan</name><name sortKey="Lai, Sik O" sort="Lai, Sik O" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name><name sortKey="Lau, Yu Ung" sort="Lau, Yu Ung" uniqKey="Lau Y" first="Yu-Lung" last="Lau">Yu-Lung Lau</name><name sortKey="Leung, Chi Ai" sort="Leung, Chi Ai" uniqKey="Leung C" first="Chi-Wai" last="Leung">Chi-Wai Leung</name><name sortKey="Li, Iris W S" sort="Li, Iris W S" uniqKey="Li I" first="Iris W. S." last="Li">Iris W. S. Li</name><name sortKey="Ng, Tak Eung" sort="Ng, Tak Eung" uniqKey="Ng T" first="Tak-Keung" last="Ng">Tak-Keung Ng</name><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S. M." last="Peiris">Joseph S. M. Peiris</name><name sortKey="Tsang, Tak In" sort="Tsang, Tak In" uniqKey="Tsang T" first="Tak-Yin" last="Tsang">Tak-Yin Tsang</name><name sortKey="Tse, Herman" sort="Tse, Herman" uniqKey="Tse H" first="Herman" last="Tse">Herman Tse</name><name sortKey="Yuen, Kwok Ung" sort="Yuen, Kwok Ung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Ung" sort="Yuen, Kwok Ung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></country><country name="Hong Kong"><noRegion><name sortKey="Yuen, Kwok Ung" sort="Yuen, Kwok Ung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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